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With the need for better predictive models for pre-clinical testing and the development of more advanced technologies to keep (human) cells alive, organ-on-a-chip technologies have become increasingly important in the drug development process.
TNO has a long track record in understanding the biology in disease development and drug PK and metabolism. In the last five years TNO invested in connecting those two with its expertise in Organ on a chip technology to find its application in better predictive, non-animal alternatives for drug efficacy and ADME testing.
This has led to the development of a liver on a chip model to test drug efficacy (in NASH/fibrosis) as well as an InTESTine on a chip model to study ADME and the effects of microbiome on drug metabolism.