Dr. ir. Han van de Sandt
- Sustainable innovation
- risk management
We focus on five social themes.
TNO cooperates with companies, the public sector and other organisations, to apply our knowledge and expertise with and for others.
We develop knowledge not for its own sake, but for practical application.
TNO offers you the chance to do groundbreaking work and help customers and society with innovative, practical and smart solutions.
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Metabolic Health Research (MHR) helps to reduce the burden of metabolic diseases such as type 2 diabetes and obesitas and their complications on patients and society by contributing to the development of new drugs, novel functional foods, new diagnostics and prevention. Major clients are biotech, pharma, diagnostic and nutrition industry, as well as patient organizations and governments. MHR is focused on preclinical research.
MHR develops and performs in vitro and in vivo models to study mechanisms, interventions and biomarkers in metabolic diseases and their complications. These translational models include unique (humanized) transgenic mouse models, in vivo and in vitro fibrosis models, read-out systems employing i.a. histology, biochemical assays, cell biology, molecular biology, immunology and inflammation markers. This preclinical research is strongly translational and aims to improve the predictability of efficacy and safety of pharmaceutical and food interventions by detailed knowledge of disease processes and mechanisms. MHR has a track record in applied science, study design, professional project management and quality systems. MHR offers customized services that can be tailored to customer needs by direct interaction of scientists of MHR and the customer.
MHR performs projects with biotech, pharma , diagnostic and food companies, governments, patient organizations and public private partnerships. The projects are characterized by a combination of knowledge and expertise in the area of metabolic health, metabolic disease and its complications such as: micro and macro vascular disease, atherosclerosis, liver steatosis, fibrosis and osteoarthritis.
MHR research leads to novel insights and opportunities to treat metabolic diseases as exemplified by:
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