Thérèse Maarschalkerweerd BSc
- Failure analysis
- Environmental forensics
- Particle size distribution
- Particle analysis
- Fibre analysis
TNO offers microscopic services for identification of particulate matter in a wide array of pharmaceutical products and medical devices, including:
TNO can identify and characterize particulate matter in these products, no matter whether the contaminant is of inherent origin (e.g. protein agglomerates), originates from the production process or from the product’s primary packaging (e.g. glass, rubber, aluminum, plastic) or is of extrinsic origin (e.g. synthetic fibers, paper, corrosion products, skin flakes).
Typical particulate matter investigations usually involve the following steps:
Experts at TNO are highly skilled in handling and isolation of small particles from complex matrices, a step that is usually crucial for successful particle identification. Particle identification itself is usually performed using a combination of:
These techniques are optimized for small particle analysis and thereby permit the identification of particles that are too small for identification with conventional chemical analysis techniques. The results of these analyses, together with the background information of the client and the expertise of the TNO experts usually enable the identification of the source of the particulate matter contamination.