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Biomarker analytics of satiation and satiety

Obesity is a clear and present danger in our society and is a severe threat to the health and wellbeing of citizens throughout the world. Energy imbalance, eating too much calories and a lack of physical activity, is considered the main cause of obesity. Satiation and satiety plays an important role in constrain of food consumption.

There is a need for objective physiological measures substantiating subjective feelings of hunger and satiety influencing actual food intake. Biomarkers of satiation and satiety are a versatile tool for assessing the potential satiating efficiency of functional ingredients or complete foods concepts and for understanding the regulation of food intake and energy balance. TNO is a reliable, fast and cost effective service provider for the analysis of these complex biomarkers of hunger and satiety. This analytical service for the qualitative and quantitative measurement of biomarkers for satiety and satiation has been proven its value for quite some years now. Biomarkers include: CCK, GLP-1, GLP-2, Bombesin, Somatostatin, Insulin, Leptin, Adiponectine (multimeric), GIP, Ghrelin, PYY, Enterostatin.

Scientific Reference:

Biomarkers of satiation and satiety
De Graaf, C., Blom, WAM, Smeets, PAM, Stafleu, A & Hendriks, HFJ.
(2004) Am. J. Clin. Nutri. 79:946-961.

Benefits working with TNO

  • Small volumes, multi-component analytics
  • Common (plasma) as well as difficult or unusual matrices (e.g. saliva, faeces, hair, milk)
  • Adaptive to special requests
  • Discovery of new biomarkers
  • Proven to be reliable, fast, professional and cost effective
  • Advice on sample handling, logistics (including protocols for proper inhibition of degradation processes)

Specified information

A distinction can be made between biomarkers of satiation or meal termination and those of meal initiation related to satiety.
Satiation: Physicochemical measures related to stomach distension and blood concentrations of cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) are biomarkers associated with meal termination.
Satiety: Currently available biomarkers for satiety are decreases in blood glucose in the short term (2–4 d) negative energy balance; and ghrelin concentrations, which have been implicated in both short-term and long-term energy balance.
Advanced Analytics: TNO has the state_of_the_art analytical infrastructure to measure all relevant biomarkers. Analytical tools and methodologies include: multiplex analysis, Luminex analyis, Meso scale discovery, RIA, ELISA and a range of validated LC-MS methodologies.


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