It takes about a decade to develop a new drug and costs many billions. Often only to find during the last phase of clinical trials that the active ingredients are not sufficiently effective or have undesirable side effects. This destroys capital. TNO has developed TargetTri, a platform that identifies and assesses the risks of undesirable side effects early in the drug development process. This significantly reduces the chance of failure.
Early insightM
When developing a new drug, pharmaceutical companies need to gain insight into possible side effects early on. The web-based platform meets this need. The drug development process starts with the identification of a drug target. This is the protein in the human body targeted by the drug to inhibit the progress of a disease or stimulate other biological processes.
Ability to interpret data
TNO has been producing Target Safety Assessments (TSA) for some time. These reports identify the safety risks of new drug targets based on the literature and other publicly available data and enable evaluation of side-effect risks. We have now perfected this process. Our ability to gather relevant data from multiple sources and interpret it allows us to produce a well-founded analysis. Artificial intelligence (AI) and machine learning play an essential role in this process.
Wide-ranging expertise
The range of expertise brought together by TNO makes the TargetTri platform unique. We use text and data mining to gather, extrapolate and structure the right information. Our toxicologists are aware of the latest scientific developments and relevant sources. We use systems biology to study interactions between proteins and their effects. The field of computational chemistry makes important contributions in this regard as well.
More efficient, efficacious and cost-effective
By elucidating the analysis of possible side effects, TargetTri makes the so-called drug discovery pipeline far more efficient, efficacious and cost-effective. Pharmaceutical companies gain insight into the mechanisms of effectiveness and risks of the selected drug targets from the very start of the drug development process. Diverse pharmaceutical helped develop TargetTri and now use it in their research.
Get in touch
Interested in investing in the commercialisation of the platform and using TargetTri to support your activities?
- Artificial Intelligence
- Application areas
- Use cases
- Program line 1: Safe autonomous systems in an open world
- Program line 2: Responsible human-machine interaction
- Secure learning in money laundering detection
- Fair decision making in the job market
- Secure learning in diabetes-2 advice
- Diagnosing for printer maintenance
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- Desdemona: The ultimate motion simulator
- LT Lab: the TNO learning technology laboratory
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- The neurobiology of Stress
- NetForce Command: an alternative to hierarchical command and control
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- Concept Development & Experimentation
- IAMD: Integrated Air & Missile Defence
- JROADS
- FACSIM
- Helicopter studies
- MARVEL / Comprehensive Approach
- TNO ACE: Advanced CD&E Environment
- Integrated approach to Dutch Royal Navy patrol ships
- Operational analysis during military operations
- SketchaWorld: from sketch to virtual world
- Camouflage
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- Digital Resilience of The Netherlands
- LFAS - Low Frequency Active Sonar
- Tanker Remote Vision System
- Platform signatures
- TNO shapes the future of MMICs and RFICs
- CARPET: Computer-Aided Radar Performance Evaluation Tool
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- A new vision on modernizing the emergency reporting process
- Social media in the security sector
- Automatic Video Compilation and Analysis System (AVACS)
- The Dutch Cyber Cube Method: Improving Human Capital for SOCs and CSIRTs
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- FP7 Project IMPACT Europe
- Critical Infrastructure Protection (CIP) policies in Europe
- @MIGO: border control
- Smarter Surveillance, man, machine, synergy
- Cyber Security of Industrial Control Systems
- Privacy enhancing techniques in cyber security data sharing
- Driving Innovation in Crisis Management with DRIVER+
- Crisis management: new challenges, new opportunities
- The learning professional: resilient and deployable for the long term
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- Process Safety Solutions: Expertise in Handling Hazardous Conditions Safely
- Expertise groups
- Acoustics and Sonar
- Chemical, Biological, Radiological and Nuclear (CBRN) Protection
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- Modelling, Simulation and Gaming
- Networked Organisations
- Radar Technology
- Weapon Systems
- Energy Transition
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- Renewable electricity
- Towards large-scale generation of wind energy
- Offshore wind farms move up a gear
- Wind energy system integration
- Maximising the value of wind energy in the future energy mix
- Required infrastructure to integrate offshore wind into the energy system
- Safe and flexible integration and monitoring of wind farms in a hybrid energy system
- Energy islands for conversion, transport, and storage
- Wind farms in synergy with society and environment
- Keeping the electricity grid stable when there’s a surplus of wind and solar
- New wind energy technology
- Innovation and the rise of solar energy
- Solar farms respecting landscape and nature
- Solar panels on farmland
- Research innovative solar parks
- Better design of solar parks
- Savings on solar farm operations and maintenance
- Floating solar panels on inland waterbodies
- Offshore solar energy
- National Consortium Solar in Landscape
- National Consortium Solar on Water
- Field lab floating solar
- Research into environmental effects of solar, wind energy
- Solar energy on buildings and infrastructure
- Solar panels in façades
- Solar windows
- More focus on safety of solar systems
- Solar heat and PV-T
- Roofs for solar energy
- Noise barriers producing solar energy
- Solar energy in road surfaces and crash barriers
- Solar panel energy generated on dikes
- Solar and infrastructure
- Outdoor test facility for BIPV(T)
- Solar Highways
- Solar-powered cars
- Mass customization
- Solar panel efficiency
- New technologies make PV more versatile
- Webinar: Innovations in solar energy technologies
- Putting Europe back in the lead in solar panel production
- System transition
- The social aspects of the energy transition
- TNO facilities for research into environmental effects of solar and wind energy
- Effective interventions to increase energy efficiency and reduce energy poverty
- Green and Ease under one roof
- Capacity building programme for energy efficiency in industry
- Zooming in on the future to make the right choices
- Scenarios for a climate-neutral energy system
- A fair system without energy poverty
- Financing the energy transition
- LAUNCH
- Successful neighbourhood approach: motivate residents
- Towards a reliable, affordable and fair energy system
- Towards CO2 neutral industry
- Reducing CO2 emissions through capture, use and storage
- SEWGS: revolutionary CO2-reduction technology and blue hydrogen production
- STEPWISE and FReSMe: CO2 reduction solutions for the steel industry
- 3D-printing for CO2 capture productivity increase
- Multi-partner ALIGN-CCUS project
- CEMCAP
- Reduce emissions steel industry
- CO₂ capture with AVR
- On-site CO₂ Capture Services: reducing emissions cost effectively
- SEDMES: Efficient technology to convert CO2 to useful product
- Hydrogen for a sustainable energy supply
- Optimising production hydrogen
- Hydrogen storage and transport
- Hydrogen, fuel and feedstock
- H-vision: blue hydrogen to accelerate carbon-low industry
- 15 things you need to know about hydrogen
- World first: Green hydrogen production in the North Sea
- New research centre for hydrogen production
- Identifying the future international chain of green hydrogen
- Opportunities for green hydrogen for the manufacturing industry investigated
- Hydrogen from offshore wind: optimising the electricity grid
- Faraday lab: optimising and scaling up electrolysis
- Blue hydrogen paves the way for green hydrogen
- Biomass to fuels and feedstock
- ARBAHEAT - Sustainable future for coal-fired power stations possible through conversion to biomass
- AMBITION Advanced biofuel production from lignin rich residues
- BECOOL EU Brazilian cooperation on advanced biofuels
- Horti-BlueC - a new EU cooperation on reducing Bio-waste and CO2-footprint in horticulture
- UNRAVEL - valorization of lignocellulosic biomass
- MacroFuels advanced biofuels from seaweed
- BRISK2 Biofuel Research Infrastructure for Sharing Knowledge
- New facility for seaweed processing
- TORWASH technology successful for waste water treatment and recycling plastics
- Biofuels lab: Making transport more sustainable with biofuels
- Take-Off: Sustainable aviation fuels from CO2, water and green energy
- HEREWEAR: Circular textiles from locally-sourced bio-based materials
- Transition to e-fuels: a strategy for HIC Rotterdam
- Re-use of existing infrastructure to accelerate the energy transition
- Sustainable Industrial Heat System
- 4 pioneering routes to a CO2 neutral industry
- Research facility Industrial Electrification accelerates greening of Rotterdam port
- Mollier facility: innovating in industrial drying technology
- Research facility for negative CO2 emissions
- Carnot lab accelerates sustainable industrial heat management
- Using energy and raw materials efficiently in industry
- e-Missi0n MOOI: TNO supports Dow and Shell in electric cracking
- CO2 reduction requires improvement of industrial processes
- Making the industrial energy transition feasible and affordable
- Accelerating sustainable industry TNO Green Print
- Sustainable subsurface
- Geological Survey of the Netherlands
- Geological Survey of the Netherlands
- 100 years of geological mapping
- GeoTOP
- Sand, gravel and clay extraction
- GIS and other tools for interactive planning
- DINO, Data and Information of the Dutch Subsurface
- BRO: the Dutch Key Register of the Subsurface
- Sustainable use and management Flemish-Dutch subsurface
- Petroleum Geological Atlas of the Southern Permian Basin
- 3D Subsurface mapping of the Dutch offshore
- Geological Survey of the Netherlands across borders
- Towards an energy-producing environment
- Expertise
- Advisory Group for Economic Affairs
- Biobased and Circular Technologies
- Geo Data & IT
- Geomodelling
- Heat Transfer & Fluid Dynamics
- Applied Geosciences
- Solar Energy
- Solar Technologies & Applications
- Sustainable Process & Energy Systems
- Sustainable Technologies for Industrial Processes
- Wind energy
- Energy transition studies
- Industry
- Roadmaps
- Flexible & Free-form Products
- Space & Scientific Instrumentation
- Semiconductor Equipment
- Smart Industry
- Expertise groups
- Buildings, Infrastructure & Maritime
- Roadmaps
- Safe and Sustainable Living Environment
- Infrastructure
- Sustainable buildings: towards an energy-producing built environment
- Building innovation
- Greenhouse design
- Digitisation in construction
- Smart megastructures
- Expertise groups
- Circular Economy & Environment
- Roadmaps
- Circular economy
- Environment & Climate
- Sustainable Chemical Industry
- Expertise groups
- Healthy Living
- Roadmaps
- Health Technology & Digital Health
- Biomedical Health
- Work
- Youth
- Expertise groups
- Traffic & Transport
- Roadmaps
- SMART and Safe Traffic and Transport
- Societal impact for accessibility and liveability
- Decision-making information based on facts for municipalities
- Making disruptive technologies practicable
- Accessible, healthy and vibrant cities
- CITYkeys – Performance evaluation framework for smart cities and projects
- Big data ecosystems: collaborating on data-controlled cities
- Knowledge mediator puts an end to bickering
- Intact – Climate resilient critical infrastructure
- Organising mobility
- Smart mobility and logistics
- Smart vehicles
- Smart Mobility Research Centre SMRC
- Sustainable Traffic and Transport
- Sustainable Mobility and Logistics
- Improving air quality by monitoring real-world emissions
- Emission factors for road traffic
- Measuring the emissions of powered two wheelers
- Emissions of particulate matter from diesel cars
- Random Cycle Generator
- EnViVer: model traffic flow and emissions
- Measuring real-world emissions with TNO’s Smart Emissions Measurement System (SEMS)
- Measuring the emissions of trucks and buses
- Reducing Greenhouse Gas Emissions in Commercial Road Transport
- Measuring the emissions of non-road mobile machinery
- Emission measures in practice
- The transition to CO2-neutral mobility in 2050
- Sustainable Vehicles
- Innovative technologies for zero-emission vehicles
- CO2 reduction by high-efficiency Flex Fuel technology with extremely low emissions
- Actual energy consumption and emissions
- Automotive Battery Research
- Making transport more sustainable by means of electric vehicles
- Energy Efficient Electric Bus E3Bus
- eCoMove
- How hydrogen can accelerate energy transition in the transport sector
- Green performance of ships
- Expertise groups
- Information & Communication Technology
- Roadmaps
- Fast open infrastructures
- Data sharing
- Trusted ICT
- Efficiency, effectiveness, quality and the costs of systems
- Expertise groups
- Strategic Analysis & Policy
- Expertise groups
- Strategic Business Analysis
- Strategy & Policy
- Orchestrating Innovation
- Tech Transfer
Eddy Zwier MSc
- Technology transfer
- Startups
- Spin-offs
- Corporate venturing
Send a question to Eddy Zwier MSc
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