Daan Noort

POSITION: CHEMISTRY & BIOLOGY
TNO UNIT: DEFENSE, SAFETY & SECURITY (CBRN PROTECTION)
UNIVERSITY:
 
TNO LOCATION: RIJSWIJK
EMAIL: DAAN.NOORT@TNO.NL
TEL: +31613189548

RESEARCH AREA

With a background in organic chemistry, my research interests lie in the following topics:

  • Evaluation of chemical detection and identification systems under laboratory and field conditions.
  • Development of identification and diagnostic methods for biological threat agents, making use of both mass spectrometry as well as novel, synthetic biology-based methods.
  • Development and evaluation of methods for diagnosis and verification of exposure to chemical warfare agents and related compounds, including forensic attribution.
  • New concepts for medical treatment of casualties exposed to C-agents, within both a civil as well as a military context.

Ambitions are to strengthen the relationships with national and international research institutes, industrial partners and universities, and expand our knowledge to civil CBRN defense. These ambitions are completely covered by the DSS Roadmap “Protection, Munitions & Weapons”.

RECENT RESULTS

Most significant recent result comprises an international collaboration with OPCW and the German Bundeswehr, and deals with the unequivocal analysis of authentic biomedical samples taken from a deceased victim after an alleged attack with chemical agents in the Syrian conflict. It is the first open scientific publication describing the analysis of such authentic samples, providing unequivocal evidence for the use of nerve agents in the Syrian conflict.

Another hallmark is my membership of the Scientific Advisory Board (since 2018) of the Organisation for the Prohibition of Chemical Weapons (OPCW), as first Dutch citizen. The OPCW is the international chemical weapons ‘watchdog’ and the winner of the 2013 Nobel Peace Prize.

Finally, my chairmanship of NATO-RTG 306 “Translating medical chemical defence research into operational medical capabilities against chemical warfare agent threats” allows me to connect with many fellow scientists with similar interests.

PHD SUPERVISION

  • Luc Bischoff, TNO/Ministry of Defence

TOP PUBLICATIONS

  • Carmany D, Walz AJ, Hsu FL, Benton B, Burnett D, Gibbons J, Noort D, Glaros T, Sekowski JW. Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX. Chem. Res. Toxicol. 30, 1076-1084, 2017
  • John H, Van der Schans MJ, Koller M, Spruit HET, Worek F, Thiermann H, Noort D. Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network. Forensic Toxicol. 2018;36(1):61-71.
  • Capacio B, Noort D et al, Clinical Detection of exposure to chemical warfare agents (2019). Chapter in: ‘Chemical Warfare Agents: Biomedical and Psychological Effects, Medical Countermeasures, and Emergency Response. (Ed. Lukey, Romano, Salem). CRC Press. eBook ISBN: 9781498769235

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