Informatietype:
Project
Unit:
High Tech Industry

CollaneX Therapeutics: working on a breakthrough in the fight against fibrosis

Fibrosis is the excessive formation of connective tissue in an organ or tissue; it is known from scars, but it can also occur in the liver as a result of obesity. An unhealthy lifestyle causes liver fibrosis to increase to such an extent that the disease almost begins to take on epidemic proportions, and no medicine is yet available. TNO has built up unique knowledge over the past decade that it wants to co-develop further with market parties into an effective medicine. This is currently being done by the newly founded CollaneX Therapeutics, a spin-off company of TNO. This biotech company will develop medicines against fibrosis, initially during the first phase of development independently, later in collaboration with pharmaceutical companies.

Working on a breakthrough in the fight against fibrosis

Fibrosis is the excessive formation of connective tissue in an organ or tissue; it is known from scars, but it can also occur in the liver as a result of obesity. An unhealthy lifestyle causes liver fibrosis to increase to such an extent that the disease almost begins to take on epidemic proportions, and no medicine is yet available. TNO has built up unique knowledge over the past decade that it wants to co-develop further with market parties into an effective medicine.
This is currently being done by the newly founded CollaneX Therapeutics, a spin-off company of TNO. This biotech company will develop medicines against fibrosis, initially during the first phase of development independently, later in collaboration with pharmaceutical companies.

Number of patients growing

Efforts to develop anti-fibrosis medicines are happening worldwide. Fibrosis can occur in many organs, such as the heart, lungs, liver and kidneys, and the number of patients with liver fibrosis is rising sharply. In the US alone 130 million people are affected by obesity, which in many cases leads to liver disorders and consequently an increase in the number of liver transplants as a result of fibrosis.

Why from TNO?

As a TNO spin-off, CollaneX has unique knowledge of both the disease and the pharmaceutical market. The scientists forming the company have developed numerous models that provide insight into the mechanisms of the disease as well as identified a unique target that helps to develop a medicine with potentially few side effects. The unique combination of knowledge of mechanisms, models and the market has convinced CollaneX that it can make a breakthrough in the fight against fibrosis.

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Angèle Reinders new director Solliance

Informatietype:
News
1 February 2023

Angèle Reinders, professor at Eindhoven University of Technology (TU/e), has been appointed Solliance's new director. Reinders will lead the new broad focus of the Dutch/Flemish/German solar energy partnership.

Critical raw materials: will their scarcity impede the energy transition goals?

Informatietype:
Article

Resource scarcity is on the rise. How do we secure Europe from critical raw materials? At TNO, we are working on answers with research.

Discover hybrid working 2.0: virtual meetings in the metaverse

Informatietype:
Insight
26 January 2023

Positive experiences of remote working are leading us to insights for new innovations. Our latest innovation: work meetings in the metaverse.

MaterialsNL Strategic Autonomy National Research Agenda

Informatietype:
Event

The energy transition is consuming enormous quantities of already scarce critical raw materials including lithium, cobalt and rare earths. Raw materials shortages are only just starting, the geopolitical implications are already being felt, as are the appeals to our morality: how do we relate to the earth and the growth paradigm?

Startdatum:
-
Locatie:
TNO Utrecht, Princetonplein 6, 3584 CB Utrecht

TNO and TECNALIA collaborate on Digital Twins for Smart & Sustainable Cities

Informatietype:
News
20 January 2023

TNO and TECNALIA Research & Innovation from Spain have announced a new cooperation agreement to establish a strategic partnership in applied research for smart and sustainable cities, mobility and enabling technologies, in particular Local Digital Twins. Representatives of both organisations signed a Memorandum of Understanding to this effect in Bilbao on 11th January 2023.