Internship | Toxicity Testing of Microplastics

Microplastics are increasingly recognized as environmental contaminants with potential health risks. Despite growing concern, the mechanisms by which microplastic particles affect human health remain unclear. One possible pathway is the induction of oxidative stress through increased production of reactive oxygen species (ROS).

In this internship, you will investigate whether exposure to microplastic particles leads to oxidative stress in cell models by measuring ROS generation. You will gain hands-on experience with cell culturing, microplastic particle handling, and in vitro toxicity testing. Next to common cytotoxicity assays, flow cytometry (FACS) will be used as a key method to quantify ROS levels and assess cellular responses. You’ll process and analyze experimental data, discuss findings in lab meetings, and present the results in reports.
You will be part of the RAPID (Risk Analysis of Product in Development) team located in Utrecht and the Human Cell Biology (HCB) research group located in Leiden. Importantly, the experimental work will be performed in TNO's research facilities in Leiden.

We are looking for a motivated master's student in a relevant field (such as toxicology, biomedical sciences, or molecular biology) with hands-on experience in in vitro cultures (required) and preferably FACS. A background or strong interest in toxicology or particle research is appreciated. The ideal candidate can work independently, is persistent, eager to learn and to overcome challenges, communicates well, and enjoys teamwork.

You want an internship opportunity on the precursor of your career; an internship gives you an opportunity to take a good look at your prospective future employer. TNO goes a step further. It’s not just looking that interests us; you and your knowledge are essential to our innovation. That’s why we attach a great deal of value to your personal and professional development. You will, of course, be properly supervised during your work placement and be given the scope for you to get the best out of yourself. Furthermore, we provide:

• A highly professional, innovative internship environment, within a team of top experts.
• A suitable internship allowance (615 euro for wo-, hbo- and mbo-students, for a full-time internship).
• Possibility of eight hours of free leave per internship month (for a full-time internship).
• A free membership of Jong TNO, where you can meet other TNO professionals and join several activities, such as sports activities, (work-related) courses or the yearly ski-trip.
• Use of a laptop.
• An allowance for travel expenses in case you don’t receive an OV-card.

At TNO, we innovate for a healthier, safer and more sustainable life. And for a strong economy. Since 1932, we have been making knowledge and technology available for the common good. We find each other in wonder and ingenuity. We are driven to push boundaries. There is all the space and support for your talent and ambition. You work with people who will challenge you: who inspire you and want to learn from you. Our state-of-the-art facilities are there to realize your vision. What you do at TNO matters: impact makes the difference. Because with every innovation you contribute to tomorrow’s world. Read more about TNO as an employer.

At TNO we encourage an inclusive work environment, where you can be yourself. Whatever your story and whatever unique qualities you bring to the table. It is by combining our unique strengths and perspectives that we are able to develop innovations that make a real difference in society. Want to know more? Read what steps we are taking in the area of diversity, equity and inclusion.

After the first CV selection, the application process will be conducted by the concerning department. TNO will provide a suitable internship agreement. If you have any questions about this vacancy, you can contact the contact person mentioned below.

For this internship vacancy it is required that the AIVD issues a security clearance (VGB) after conducting a security screening. Take into account that this process may take about 8 weeks. If you have been abroad for more than 6 consecutive months, or if you do not have the Dutch nationality, it may take longer. Read more about security screening on the AIVD website.

Important to be aware of before applying:

• Before the start of the internship, the internship agreement from TNO needs to be signed. For students at a college or university based in the Netherlands, TNO uses the UNL-template (supplemented with a number of specific agreements from TNO). For students of foreign and MBO educational institutions, the TNO internship agreement applies. TNO does not sign any other internship agreements.
• Before the start of the internship, the educational institution will need to confirm in writing that:
  • 1) you are enrolled at the educational institution during the internship, and;
  • 2) the internship takes place as part of the programme of the study.
• The confirmation of educational institution takes place by signing the UNL template or forms prepared by TNO.
• Interns at TNO must be in possession of a Dutch residential address at the start of the internship. Performance of internship activities from abroad is not possible.