Jelle de Jong

Functie:
Scientist

My research focuses on skeletal muscle function and physiology during ageing and frailty, with specific interest in sex differences. I integrate human cohorts, intervention studies, and cell and animal models in a translational approach to uncover mechanisms, develop digital and wet biomarkers, and advance personalized interventions that improve muscle health across the lifespan.

Relevant publications

  • De Jong, J. C., Attema, B. J., Van Der Hoek, M. D., Verschuren, L., Caspers, M. P., Kleemann, R., Van Der Leij, F. R., Van Den Hoek, A. M., Nieuwenhuizen, A. G., & Keijer, J. (2023). Sex differences in skeletal muscle-aging trajectory: same processes, but with a different ranking. GeroScience, 45(4), 2367–2386. https://doi.org/10.1007/s11357-023-00750-4.

  • De Jong, J. C. B. C., Caspers, M. P. M., Worms, N., Keijzer, N., Kleemann, R., Menke, A. L., Nieuwenhuizen, A. G., Keijer, J., Verschuren, L., & Van Den Hoek, A. M. (2024). Translatability of mouse muscle-aging for humans: the role of sex. GeroScience, 46(3), 3341–3360. https://doi.org/10.1007/s11357-024-01082-7.

  • De Jong, J. C. B. C., Jameson, T. S. O., Andrews, R. C., Dunlop, M. V., Abdelrahman, D. R., Murton, A. J., Caspers, M. P. M., Worms, N., Van Nieuwkoop, A., Keijzer, N., Cheng, Q., Guigas, B., Van Duijn, E., Vaes, W. H. J., Nieuwenhuizen, A. G., Keijer, J., Wall, B. T., Verschuren, L., Stephens, F. B., . . . Dirks, M. L. (2025). Anabolic effects of salbutamol are lost upon immobilization. Journal of Cachexia Sarcopenia and Muscle, 16(6), e70114. https://doi.org/10.1002/jcsm.70114.

  • Van De Meene, M. R. C., Van Den Hoek, A. M., Hanemaaijer, R., Verschuren, L., & De Jong, J. C. B. C. (2025). In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells. Experimental Physiology. https://doi.org/10.1113/ep092677.

  • Van Den Hoek, A. M., De Jong, J. C., Worms, N., Van Nieuwkoop, A., Voskuilen, M., Menke, A. L., Lek, S., Caspers, M. P., Verschuren, L., & Kleemann, R. (2021). Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk. Metabolism, 124, 154873. https://doi.org/10.1016/j.metabol.2021.154873.

Leiden - Sylviusweg

Sylviusweg 71
2333 BE Leiden
The Netherlands