Digital Biomarker Lab: trusted digital biomarker development and validation from daily-life data

From digital measures to validated digital biomarkers

At the TNO Digital Biomarker Lab, we use a structured pathway to develop digital biomarkers that are trustworthy, interpretable, and meaningful in daily life, so they can support decisions in clinical research and healthcare.

We take a rigorous, independent, and patient-centric approach. We start with the question that matters most: what do patients and clinicians need to understand, monitor, or improve? From there, we define the intended context of use and build the evidence package required for adoption, scientifically, operationally, and, where relevant, regulatory-aligned.

Because digital biomarkers are increasingly used in settings where quality and transparency expectations are high, we are regulator-aware in how we design evidence generation. In many settings, digital biomarkers will only be useful at scale if they meet expectations for quality, validation and transparency. We help clients and partners navigate these requirements in practice, so digital biomarkers can move from promising signals to credible, usable tools in the real world.

Building on long-standing experience in measuring health and behaviour, TNO combines scientific depth with practical expertise in digital health and clinical research.

Services: digital biomarker discovery, validation and remote data collection

We support partners across key stages of the digital biomarker lifecycle. By combining discovery, validation, patient engagement and data infrastructure, we enable clients and partners to build digital biomarkers that are robust, interpretable and ready to be used, whether in clinical research, healthcare practice or real-world settings.

Portfolio: turning evidence into impact through projects and partnerships

The TNO Digital Biomarker Lab builds on more than 20 years of expertise in measuring health and behaviour, combined with the team’s focused experience in digital biomarker development across multiple therapeutic areas.

Our projects span chronic inflammatory, cardiovascular, metabolic, neurological and sleep-related conditions, delivered in close collaboration with partners from industry, academia and healthcare. Through scientific rigour and fit-for-purpose digital measures, we translate complex sensor-derived data into meaningful evidence that supports innovation in medicine.