Steven Erpelinck BSc. MBA
- AMS transporters
- PBPK modeling
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We will also show our in vitro microbiota screening platform I-screen which can be used in preclinical phase to measure and identify microbiota induced 'human' metabolites.
A microdosing AMS study requires a very low dose (< 100ug), reduces costs, shortens the development process and ensures a reduction of lab animals during preclinical development. TNO is the only organisation in Europe with an auto-combustion based biomedical Accelerator Mass Spectrometer (AMS) that enables this research.
At the ACCP, TNO will present its capabilities in the field of microdosing AMS studies showing that these studies may accelerate and de-risk drug development. Advantages of our auto-combustion based AMS in comparison to the conventional graphitisation based AMS will be demonstrated. We look forward to meeting you at our booth, number 202.