What's new in in vitro microbiome and ex vivo intestinal models for gut health

Webinar • 09 Nov 2021

We cordially invite you to attend the webinar where we introduce our latest developments in in vitro models for the study of gut microbiota dynamics and host intestinal tissue response on November 9, 3.00 - 4.00 pm (CET). Register now to join the webinar.

The webinar

Gut health is a key factor in our overall health and well-being. The gut microbiome that inhabits the digestive environment of the gut lumen contributes to intestinal homeostasis. Food products, drugs, probiotics and other factors can influence the function of the gut wall and/or microbiome.

Our translational models can be used to study the impact of your product on gut microbiota and host tissue response and can help to evaluate and boost product innovation at an early stage. Our in vitro and ex vivo gut model systems provide the unique opportunity to screen different lead compounds, ingredients and solutions for specific target populations (obese, elderly, infants) and evaluate their potential to promote health.


  • Introduction gut health innovations - Edwin Abeln, senior business developent manager TNO
  • Microbiome modulation and activity – Maria Wiese, senior scientist microbiology, TNO
    The i-screen in vitro model is an excellent platform for the study of gut microbial community dynamics and facilitates the screening of pre- probiotics, drugs, fibre, polyphenols. Experimental downstream analysis facilitates in depth community composition analysis as well as insights into microbial metabolites. We will furthmore introduce our new development such as for instance the i-screen -CD an in vitro diseased gut model for the screening of novel solutions preventing of Clostridioides difficile infection, as well as the i-screen-RS for gut microbiome restoration.
  • Intestinal wall function – Joanne Donkers, medior scientist human cell biology, TNO
    Intact ex vivo intestinal tissue is used in our models of the gut wall, InTESTine™ and the Intestinal Explant Barrier Chip (IEBC). The wells-plate or microfluidic chip setup allows monitoring many processes that take part at the gut wall, such as transport, barrier function, metabolic activity, hormone secretion, and the inflammatory response. Special attention will be paid to the possibility to study the impact of your compound on the gut tissue as well as on the interaction of the gut wall with the microbiome.

Collaboration projects

Next to the established models we also will share ideas to collaborate on novel ideas:

  1. Interaction of the gut microbiome and polyphenols for better health.
  2. Host microbiome interactions: an aerobic-anaerobic interface is to facilitate the direct interaction of the anaerobic gut microbiome with intestinal tissue in the IEBC platform.
  3. Mucosal colon model: An in vitro model for the study of gut mucosa-associated microbiota in health and disease.
  4. Fontanelle: For studying intestinal health in early life: integration of gut tissue, microbiome and lymphoid tissue.

We are looking forward to meeting you online on November 9th! 

Register to join the webinar

If you are working in the field of gut health innovations and want to learn about the latest developments in In vitro microbiome and ex vivo intestinal models.

Our work

Microbiome: expertise and analysis

Determine microbiota composition in human subjects, and allow for accurate measurement and monitoring of microbiomes in various stages of scientific research to accelerate advancement and discovery. TNO... Read more

Biomedical Health

Healthcare costs are rising. We can and will do something about it. In the context of the Biomedical Health roadmap, we are developing the tools and expertise needed to help companies, professionals and... Read more

Dr. Edwin Abeln

  • microbiology
  • preservation
  • guthealth
  • healthy food
  • feed