Digital health
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Organ on a chip

With the need for better predictive models for pre-clinical testing and the development of more advanced technologies to keep (human) cells alive, organ-on-a-chip technologies have become increasingly important in the drug development process.

Organ-on-a-chip technologies

TNO has a long  track record in understanding the biology in disease development and drug PK and metabolism. In the last 5 years TNO invested in connecting those two with its expertise in Organ on a chip technology to find its application in better predictive, non-animal alternatives for drug efficacy and ADME testing.

This has led to the development of a liver on a chip model to test drug efficacy (in NASH/fibrosis) as well as an InTESTine on a chip model to study ADME and the effects of microbiome on drug metabolism.

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