Risk analysis for products in development

Thema:
Healthy society

RAPID studies the health effects of exposure to hazardous substances in the workplace, in the environment, and after intake. It develops innovative approaches for early prediction of health effects resulting from such exposure, as well as measuring, modelling, and managing exposure. We do this research within national and international legal frameworks, and we focus on earlier process phases, such as the development of new ingredients, materials, and products by means of Safe and Sustainable by Design concepts.

Health risks of hazardous substances

On the basis of RAPID, we’re increasingly modelling health risks of hazardous substances for humans in order to reduce costs and increase speed. In doing so, we combine in-depth knowledge of risk analysis and statistics with practical experience in the field of innovative experimental research. This includes research into toxicology, immune health, epidemiology, chemistry, human exposure, statistics, and modelling. For example, we’re developing integrated strategies that predict human health risks with high precision and make minimal use of animal studies.

We use the Diamonds data platform to integrate data for Life Sciences in various domains, such as risk assessments of substances, safety assessments of drug targets, and decision support systems for personalised advice.

Our expertise

The focus of RAPID is to demonstrate whether innovations work to a sufficient degree (proof of principle), and to deliver a first application, in which the working principle is used (proof of market). With external partners, we shape the further upscaling of a significant part of these innovations in the private market.

We’re strongly internationally oriented and focus on industrial challenges within three business sectors:

  1. chemistry
  2. pharma
  3. food

We also support governments with their research issues.

Applications and impact

Some examples of our applications with their impact on society:

  • Based on research among a large number of industry organisations, we conclude that many Dutch citizens may be exposed to nanoparticles in the workplace. These results serve as a basis for new large-scale research into nanoparticle exposure among Dutch workers.
  • We’ve shown that the concentration of allergens in foodstuffs can cause public health risks through cross-contamination. A model we developed calculates the number of consumers who have an allergic reaction to a certain concentration of an allergen in food. Our research and the international database managed by TNO, with more than 3500 sensitivity thresholds in individual patients with food allergies, form the basis for WHO/FAO advice on safe limits for allergens in food.
  • RAPID plays a leading role in developing the multidisciplinary exposome paradigm. The exposome identifies multifactorial health stressors, resulting from multiple and lifelong exposure, in relation to health effects. The exposome is taking on an increasingly significant role in determining/measuring health and developing strategies for health interventions.
  • RAPID has developed a digital text-mining application called Target Tri to help pharmaceutical companies with the early selection of new drug targets. Target Tri can quickly establish the safety and effectiveness of targets.

Connecting the dots for effective disease prevention

Read our white paper on how environmental exposures are a major risk factor for disease.

Get inspired

17 resultaten, getoond 6 t/m 10

TNO's view of 2030: 50% reduction in lifestyle-related diseases

Informatietype:
Insight
14 November 2022

We look ahead to 2030 and find out, among other things, how we can offer people a healthy environment and with a healthier lifestyle.

Translational models TNO excel in preclinical research

Informatietype:
Insight
13 June 2022
TNO’s animal models for NAFLD/NASH are the most translational to human tissue data in a recent Hepatology article about NAFLD/NASH and cardiovascular disease.

Public Private Partnership Arla Food Ingredients and Danone

Informatietype:
Insight
17 March 2022
TNO Healthy Living, Arla & Danone built an in silico model to identify markers needed to assess safety & efficacy of an immune intervention in infants.

International Women’s Day 2022

Informatietype:
Insight
8 March 2022

Today on International Women’s Day we celebrate the success and achievements of women in science for breaking down barriers and challenging the status quo. Get to know some of TNO’s women contributing to a sustainable society every day.

Successful results mental health program to displaced children

Informatietype:
Insight
25 January 2022
TNO and Help a Child developed BoB, Build your Own Buddy, to help displaced families in South Sudan empower themselves to cope with stress and trauma.