Microbiology & Systems Biology
The Microbiology & Systems Biology (MSB) department of TNO focuses on the most pressing health challenges facing the lifestyles of a changing, modern society. We foresee the evolution towards personalized health and a priority for individual needs within the context of an aging population and continued urbanization by applying our experience and expertise to these urgent health issues.
The Minutiae & the Whole
From the tiniest microorganisms to the entirety of the human corporeal, we examine the full spectrum of mechanical and biochemical processes with the most state-of-the-art analytical platforms. The human body exhibits the signs and symptoms of illness long before full-fledged outbreak and seemingly unrelated signals may indicate impending health problems elsewhere. The oral cavity, for example, offers telling insights into the lung as oral infections are associated with an increased risk of pneumonia. The intestinal microbiota may reveal telling clues for the development of a pre-diabetic condition.
Guided by our vision to advance the human condition through healthful living, we think the best way of studying the incidence of disease is the use of relevant, predictive and translational model platforms. Whether this is through analysis of the gut microbiome with in vitro and in vivo technologies for the acceptability of an antibiotic or food ingredient, or the direct consultation for personalized dietary regimens, our mission is to provide disruptive technological solutions for a more sustainable and integrative society.
Our Focus Areas
Microbiology
Leveraging the wealth of knowledge contained within the communities of microbes, or microbiomes, that exist in and on various parts of the body to mine insights on overall health.
Systems Biology
The network dynamics of human systems becomes increasingly important in a modern society that brings light to new biological and social pathologies.
Human Biology
Our investments in discovery and the technology that aids the developmental process are a vital component of our working portfolio.
Our Success Stories
Some of our notable contributions to the global knowledge pool include collaborations with:
- Pfizer
- Johnson & Johnson
- Nestlé
- Barilla
- Gilead
- Philips
Mead Johnson - Heinz
- Friesland Campina
- Amsterdam Medical Center
- VU Amsterdam
- Leiden University Medical Center
- Erasmus University of Rotterdam
Our Science
1) T. Kelder, J.H.M. Stroeve, S. Bijlsma, M. Radonjic and G. Roeselers
Correlation network analysis reveals relationships between diet-induced changes in human gut microbiota and metabolic health
Nutrition & Diabetes (2014) 4
2) Michael M. Joosten, Marjan J. van Erk, Linette Pellis, Renger F. Witkamp and Henk F.J. Hendriks
Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men
British Journal of Nutrition (2012), 108
3) Heather R. Mattila, Daniela Rios, Victoria E. Walker-Sperling, Guus Roeselers, Irene L. G. Newton
Characterization of the active microbiotas associated with honey bees reveals healthier and broader communities when colonies are genetically diverse
PLoS ONE (2012), 3
4) Marijana Radonjic, Peter Y. Wielinga, Suzan Wopereis, Thomas Kelder, Varshna S. Goelela, Lars Verschuren, Karin Toet, Wim van Duyvenvoorde, Bianca van der Werff van der Vat, Johanna H. M. Stroeve, Nicole Cnubben, Teake Kooistra, Ben van Ommen, Robert Kleemann
Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr-/- Mice
PLoS ONE (2013), 2
5) Joke A. M. Dols, Douwe Molenaar, Jannie J. van der Helm, Martien P. M. Caspers, Alie de Kat Angelino-Bart, Frank H. J. Schuren, Adrianus G. C. L. Speksnijder, Hans V. Westerhoff, Jan Hendrik Richardus, Mathilde E. Boon, Gregor Reid, Henry J. C. de Vries and Remco Kort
Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity
BMC Infectious Diseases (2016) 16
More publications from our department can be found at the TNO Repository.
Partner with Us
The department of Microbiology and Systems Biology bring together over 150 leading scientists and experts in multi-disciplinary fields and cross-functional roles under one unified vision of healthy living. To this end, our team is on the search for organizations with the same commitment to high-quality, independent research.
Microbiome for health
Biorizon as a new route to bioaromatics
The development and up-scaling of technologies to enable the commercial production of aromatic compounds from biowaste by 2025: this is what VITO and TNO are focusing on in the shared research centre... Read moreNutriTech
Application of new technologies and methods in nutrition research - the example of phenotypic flexibility. TNO coordinates the project and leads the workpackage 'Integration'. Read more-
Solutions in Agro-Food
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Solutions in personal care
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Overview of publications of MSB (2017-2013)
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Minimising COVID-19 contamination in hospitals
How can we ensure facemask efficacy and availability?
- Artificial Intelligence
- Application areas
- Use cases
- Program line 1: Safe autonomous systems in an open world
- Program line 2: Responsible human-machine interaction
- Secure learning in money laundering detection
- Fair decision making in the job market
- Secure learning in diabetes-2 advice
- Diagnosing for printer maintenance
- Subsidence monitoring
- Fair decision making in justice
- Augmented worker for smart industry
- Energy balancing for smart homes
- Secure learning in oncology research
- Innovation monitoring in policy
- News
- Defence, Safety & Security
- Roadmaps
- Operations & Human Factors
- Climate Chambers for Research into Human Performance
- Desdemona: The ultimate motion simulator
- LT Lab: the TNO learning technology laboratory
- Performance and health monitoring
- Motion sickness and performance
- The neurobiology of Stress
- NetForce Command: an alternative to hierarchical command and control
- Operational military performance in a virtual world
- SUPRA
- Simulation Live Virtual and Constructive
- Concept Development & Experimentation
- IAMD: Integrated Air & Missile Defence
- JROADS
- FACSIM
- Helicopter studies
- Replacement of the F-16
- MARVEL / Comprehensive Approach
- TNO ACE: Advanced CD&E Environment
- Integrated approach to Dutch Royal Navy patrol ships
- Operational analysis during military operations
- SketchaWorld: from sketch to virtual world
- Camouflage
- Information & Sensor Systems
- Digital Resilience of The Netherlands
- LFAS - Low Frequency Active Sonar
- Tanker Remote Vision System
- Platform signatures
- TNO shapes the future of MMICs and RFICs
- CARPET: Computer-Aided Radar Performance Evaluation Tool
- Underwater Warfare and Security
- Wide Area Motion Imagery WAMI
- SAKAMATA: sonar and marine mammals
- PARANOID: rapid information processing
- Mine analysis and threat evaluation
- Ship acoustics and underwater acoustic signatures
- PERSEUS Wind Turbine Radar Interference Assessment tool
- Electromagnetic security
- Operating safely at sea
- Operations at sea
- Ocean Space
- National Security
- A new vision on modernizing the emergency reporting process
- Social media in the security sector
- Automatic Video Compilation and Analysis System (AVACS)
- The Dutch Cyber Cube Method: Improving Human Capital for SOCs and CSIRTs
- Concealed weapon detection
- FP7 Project IMPACT Europe
- Critical Infrastructure Protection (CIP) policies in Europe
- @MIGO: border control
- Smarter Surveillance, man, machine, synergy
- Cyber Security of Industrial Control Systems
- Privacy enhancing techniques in cyber security data sharing
- Driving Innovation in Crisis Management with DRIVER+
- Crisis management: new challenges, new opportunities
- The learning professional: resilient and deployable for the long term
- Protection, Munitions & Weapons
- Weapons systems control and analysis
- Weapon Effects & Protection Center
- Firepower
- Protection and survivability of vehicles
- Naval protection and survivability
- Infrastructure protection and survivability
- World-class ballistics research
- Countering Explosive Threats
- Materials for protection concepts
- Processing of Propellants, Explosives and Pyrotechnics
- Ammunition Safety
- Ballistic Performance and Personal Protection
- Chemical, Biological, Radiological and Nuclear (CBRN) Protection
- Anticipating accidents, incidents and threats
- Protecting those who protect us
- Process Safety Solutions: Expertise in Handling Hazardous Conditions Safely
- Expertise groups
- Acoustics and Sonar
- Chemical, Biological, Radiological and Nuclear (CBRN) Protection
- Electronic Defence
- Energetic Materials
- Explosions, Ballistics and Protection
- Human Behaviour and Organisational Innovation
- Human Machine Teaming
- Human Performance
- Intelligent Autonomous Systems
- Intelligent Imaging
- Military Operations
- Modelling, Simulation and Gaming
- Networked Organisations
- Radar Technology
- Weapon Systems
- Energy Transition
- Roadmaps
- Renewable electricity
- Towards large-scale generation of wind energy
- The important of support structures
- Wind turbines, fully in motion
- Innovation towards 10-20 MW offshore wind turbines
- Modeling 10MW+ turbines aerodynamically
- Design for Reliable Power Performance (D4REL)
- Optimised wind blade tip design
- Vortex-wake models in wind turbine design
- Modelling improvement wind turbine blades
- Converters for Clean, Low Cost Electricity
- Haliade X: largest wind turbine ever
- New research on blade tip improvements
- Less production per wind turbine, still higher yield
- Logistics innovative strength at home and abroad
- Wind turbine management and maintenance
- Wind farms in synergy with the environment
- Innovative methods for wind measurements
- Keeping the electricity grid stable when there’s a surplus of wind and solar
- Innovation and the rise of solar energy
- Solar farms respecting landscape and nature
- Solar panels on farmland
- Research innovative solar parks
- Better design of solar parks
- Savings on solar farm operations and maintenance
- Floating solar panels on inland waterbodies
- Offshore solar energy
- National Consortium Solar in Landscape
- National Consortium Solar on Water
- Field lab floating solar
- Research into environmental effects of solar, wind energy
- Solar energy on buildings and infrastructure
- Solar-powered cars
- Mass customization
- Solar panel efficiency
- New technologies make PV more versatile
- Webinar: Innovations in solar energy technologies
- Putting Europe back in the lead in solar panel production
- System transition
- The social aspects of the energy transition
- TNO facilities for research into environmental effects of solar and wind energy
- Effective interventions to increase energy efficiency and reduce energy poverty
- Green and Ease under one roof
- Capacity building programme for energy efficiency in industry
- Zooming in on the future to make the right choices
- Scenarios for a climate-neutral energy system
- A fair system without energy poverty
- Financing the energy transition
- LAUNCH
- Successful neighbourhood approach: motivate residents
- Towards a reliable, affordable and fair energy system
- Towards CO2 neutral industry
- Reducing CO2 emissions through capture, use and storage
- SEWGS: revolutionary CO2-reduction technology and blue hydrogen production
- STEPWISE and FReSMe: CO2 reduction solutions for the steel industry
- 3D-printing for CO2 capture productivity increase
- Multi-partner ALIGN-CCUS project
- CEMCAP
- Reduce emissions steel industry
- CO₂ capture with AVR
- On-site CO₂ Capture Services: reducing emissions cost effectively
- Hydrogen for a sustainable energy supply
- Optimising production hydrogen
- Hydrogen storage and transport
- Hydrogen, fuel and feedstock
- H-vision: blue hydrogen to accelerate carbon-low industry
- 15 things you need to know about hydrogen
- World first: Green hydrogen production in the North Sea
- New research centre for hydrogen production
- Identifying the future international chain of green hydrogen
- Opportunities for green hydrogen for the manufacturing industry investigated
- Hydrogen from offshore wind: optimising the electricity grid
- Faraday lab: optimising and scaling up electrolysis
- Blue hydrogen paves the way for green hydrogen
- Biomass to fuels and feedstock
- ARBAHEAT - Sustainable future for coal-fired power stations possible through conversion to biomass
- AMBITION Advanced biofuel production from lignin rich residues
- BECOOL EU Brazilian cooperation on advanced biofuels
- Horti-BlueC - a new EU cooperation on reducing Bio-waste and CO2-footprint in horticulture
- UNRAVEL - valorization of lignocellulosic biomass
- MacroFuels advanced biofuels from seaweed
- BRISK2 Biofuel Research Infrastructure for Sharing Knowledge
- New facility for seaweed processing
- TORWASH technology successful for waste water treatment and recycling plastics
- Biofuels lab: Making transport more sustainable with biofuels
- Take-Off: Sustainable aviation fuels from CO2, water and green energy
- HEREWEAR: Circular textiles from locally-sourced bio-based materials
- Transition to e-fuels: a strategy for HIC Rotterdam
- Re-use of existing infrastructure to accelerate the energy transition
- Sustainable Industrial Heat System
- 4 pioneering routes to a CO2 neutral industry
- Research facility Industrial Electrification accelerates greening of Rotterdam port
- Mollier facility: innovating in industrial drying technology
- Research facility for negative CO2 emissions
- Carnot lab accelerates sustainable industrial heat management
- Using energy and raw materials efficiently in industry
- e-Missi0n MOOI: TNO supports Dow and Shell in electric cracking
- CO2 reduction requires improvement of industrial processes
- Making the industrial energy transition feasible and affordable
- Sustainable subsurface
- Geological Survey of the Netherlands
- Geological Survey of the Netherlands
- 100 years of geological mapping
- GeoTOP
- Sand, gravel and clay extraction
- GIS and other tools for interactive planning
- DINO, Data and Information of the Dutch Subsurface
- BRO: the Dutch Key Register of the Subsurface
- Sustainable use and management Flemish-Dutch subsurface
- Petroleum Geological Atlas of the Southern Permian Basin
- 3D Subsurface mapping of the Dutch offshore
- Geological Survey of the Netherlands across borders
- Towards an energy-producing environment
- Expertise
- Industry
- Roadmaps
- Flexible & Free-form Products
- Space & Scientific Instrumentation
- Semiconductor Equipment
- Smart Industry
- Expertise groups
- Buildings, Infrastructure & Maritime
- Roadmaps
- Safe and Sustainable Living Environment
- Infrastructure
- Sustainable buildings: towards an energy-producing built environment
- Building innovation
- Greenhouse design
- Digitisation in construction
- Smart megastructures
- Expertise groups
- Circular Economy & Environment
- Roadmaps
- Circular economy
- Environment & Climate
- Sustainable Chemical Industry
- Expertise groups
- Healthy Living
- Roadmaps
- Health Technology & Digital Health
- Biomedical Health
- Work
- Youth
- Expertise groups
- Traffic & Transport
- Roadmaps
- SMART and Safe Traffic and Transport
- Societal impact for accessibility and liveability
- Decision-making information based on facts for municipalities
- Making disruptive technologies practicable
- Accessible, healthy and vibrant cities
- CITYkeys – Performance evaluation framework for smart cities and projects
- Big data ecosystems: collaborating on data-controlled cities
- Knowledge mediator puts an end to bickering
- Intact – Climate resilient critical infrastructure
- Organising mobility
- Smart mobility and logistics
- Smart vehicles
- Smart Mobility Research Centre SMRC
- Sustainable Traffic and Transport
- Sustainable Mobility and Logistics
- Improving air quality by monitoring real-world emissions
- Emission factors for road traffic
- Measuring the emissions of powered two wheelers
- Emissions of particulate matter from diesel cars
- Random Cycle Generator
- EnViVer: model traffic flow and emissions
- Measuring real-world emissions with TNO’s Smart Emissions Measurement System (SEMS)
- Measuring the emissions of trucks and buses
- Reducing Greenhouse Gas Emissions in Commercial Road Transport
- Measuring the emissions of non-road mobile machinery
- Emission measures in practice
- The transition to CO2-neutral mobility in 2050
- Sustainable Vehicles
- Innovative technologies for zero-emission vehicles
- CO2 reduction by high-efficiency Flex Fuel technology with extremely low emissions
- Actual energy consumption and emissions
- Hydrogen and the fuel cell
- Automotive Battery Research
- Making transport more sustainable by means of electric vehicles
- Energy Efficient Electric Bus E3Bus
- eCoMove
- Hydrogen for internal combustion engines in heavy equipment
- Green performance of ships
- Expertise groups
- Information & Communication Technology
- Roadmaps
- Fast open infrastructures
- Data sharing
- Trusted ICT
- Efficiency, effectiveness, quality and the costs of systems
- Expertise groups
- Strategic Analysis & Policy
- Expertise groups
- Strategic Business Analysis
- Strategy & Policy
- Orchestrating Innovation
- Tech Transfer
Ing. Daan Kloet
- Prevention
- Health
- Microbiology
- Systems Biology
- EHealth
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