Aiming for fast accurate preclinical and clinical trials

Pharma companies want it. Regulators want it. Patients certainly want it: faster, more accurate, less expensive drug development. But with all the complexity that drug development entails, how can we accelerate the process? By eliminating some of the bottlenecks that delay the critical path. TNO has developed a range of tools, technology and data that enables pharma companies to achieve their objectives more swiftly and successfully than ever before.

Insight for the industry

Successful drug development is a lengthy, expensive and complicated process. What makes TNO the ideal partner to accelerate preclinical and clinical research? Our understanding of those complexities and our technologies, which address them.

At TNO, we innovate for the benefit of the pharmaceutical and biotech industry, for society and for patients. Our preclinical models and clinical platforms have proven value, and help drug companies reach key phases more swiftly and confidently.

TNO’s translational models excel in preclinical research

TNO helps accelerate drug development through insight

TNO proves method for effective pediatric drug development

Translational preclinical models with trustworthy, meaningful results

In preclinical development stages, project leads are under pressure to identify novel targets and candidate compounds. To obtain meaningful results, early in vitro and in vivo studies should employ robust models that recapitulate critical human disease processes. TNO’s proven platforms boost preclinical research and offer insight into the efficacy, pharmacokinetics and safety of candidate compounds. We combine robust biological models with high-end analytics for specific and sensitive readouts.

Our extensive tissue biobank and database enables us to make head-to-head comparisons of preclinical testing results with pathways in human tissue or specific cells. This ensures a higher rate of translatability between early preclinical studies and later human ones.

Insight into the mechanisms of disease onset and development

In complex diseases where multiple organs are affected, understanding the pathways of disease onset and progression is key. This helps define key targets and the optimal therapeutic window, and drives more effective interventions. Time course studies that combine multiple (-omics) technologies in TNO’s translational animal models have been used to identify and validate several types of biomarkers, which improve early patient diagnosis of patients, efficacy testing of candidate drugs and patient stratification.

Our knowledge of disease mechanisms has enabled us to identify the molecular signatures of NASH-induced fibrosis in the circulation. These signatures are being validated in patient cohorts and might replace biopsies in the future. We have also uncovered molecular links between NASH and atherosclerosis development, enabling interventions that focus on the mechanisms of both diseases. We now aim to use a similar approach to gain better understanding of the processes involved in diabetic disease, and we are eager to work with partners to further increase knowledge of complex metabolic diseases.

Faster, less expensive, more accurate pharmacokinetic data

Safety Package investigations usually begin with extensive animal testing to identify key metabolites that may affect drug safety or efficacy. But animals often develop different metabolites than humans do. TNO can offer smart technologies that identify relevant human metabolites already in Phase 1. This enables targeted safety testing in animals and a stronger basis for research that completes the safety package sooner and at a lower cost.

Secondly, classical tracing studies use high doses of radiation, which raises medical ethical questions and limits their usage to late-stage clinical trials. TNO’s unique combination of microtracing (100-1000x lower radiation levels) and AMS technology enable these metabolite studies to occur in the earliest stages of clinical study. This is not only safer for patients, but also provides more accurate information, earlier in the process. Microtracing also eliminates the need for high-dose radiation studies.

Ready to accelerate and de-risk your drug development process? Contact Steven Erpelinck or Robert Ostendorf.

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TNO helps accelerate drug development through insight

Informatietype:
Insight
14 November 2022

To find the most effective interventions for complex metabolic diseases, we must first understand the dynamics of disease onset and progression. Only then can key targets and optimal therapeutic windows for more effective treatment be defined. We spoke with Anita van den Hoek, Research Scientist for TNO Metabolic Health, about how TNO helps pharmaceutical companies accelerate drug development through better understanding of disease pathways.

TNO proves method for effective pediatric drug development

Informatietype:
Insight
14 November 2022

Safe and effective drug dosing for young children come with their own challenges. Up to the age of 18, a child’s metabolism can change significantly. And in the first two years of life, those ontogenic differences can be rapid and dramatic. TNO published its findings from the first drug disposition (mass balance/metabolite profiling) study to conclusively prove that microtracing with accelerator mass spectrometry (AMS) is an effective way to collect clinical data in these young patients. This AMS technology can also be the key to building up more data on drug interventions in pregnant and lactating mothers.

Functional microbiome analysis

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Article

TNO has a wide range of available tools to increase understanding of the impact and interaction of the microbiome on human health. Learn more.

PK Studies AMS

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Article

With TNO’s microtracer expertise, drug development becomes a streamlined and targeted process.

Target safety assessment

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Article

Our unique set of assessments and web-based target triaging platform TargetTri, can help to make informed decision making easy with transparent, knowledge-driven expert views on target efficacy, safety liabilities, and risk mitigation.