Organ on a chip

With the need for better predictive models for pre-clinical testing and the development of more advanced technologies to keep (human) cells alive, organ-on-a-chip technologies have become increasingly important in the drug development process.

Organ-on-a-chip technologies

TNO has a long track record in understanding the biology in disease development and drug PK and metabolism. In the last 5 years TNO invested in connecting those two with its expertise in Organ on a chip technology to find its application in better predictive, non-animal alternatives for drug efficacy and ADME testing.

This has led to the development of a liver on a chip model to test drug efficacy (in NASH/fibrosis) as well as an InTESTine on a chip model to study ADME and the effects of microbiome on drug metabolism.

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Get in touch

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Robert Ostendorf

Functie:
Senior Business Development Manager translational pharmaceutical research
I am passionate about TNO’s unique expertise in translational (preclinical) research. My work focuses on efficacy, ADME/DMPK and target safety of new pharmaceutical interventions, with special interest in cardiovascular, metabolic and fibrotic diseases, and biomarker research.

Looking for contract research support, or see opportunities for collaboration? Please, reach out.

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- Standplaats:
  Leiden - Sylviusweg
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Jennifer McCormack-Venhorst

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Senior Scientist Integrator
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  Utrecht - Princetonlaan
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Jildau Bouwman

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Senior scientist at TNO and professor at Leiden University
Jildau Bouwman leads the strategy of the “digital health technology” program of TNO, that focusses on helping individuals to make a healthy choice using digital solutions.

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  Leiden - Sylviusweg
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Robin van Stokkum

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Data Science Consultant Health Sciences
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- Standplaats:
  Utrecht - Princetonlaan
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Suzan Wopereis

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Principal Scientist
My main research focus is studying on the understanding of what biological mechanisms drive health, how you can measure health and deviations from health and importantly on how to intervene on an individual level with lifestyle on health (personalised health).

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- Standplaats:
  Leiden - Sylviusweg
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  Email Suzan