Specialists from the entire value chain work together on the development and scale-up of the mild fractionation process, FABIOLA(TM) which has a large potential for improving the cost-effective pretreatment of biomass. The fractionation of pre-extracted agricultural, forestry and food-processing residues will result in high yields of sugars and lignin, which will be converted to fuels, building blocks for bio-based products and bio-polymers.