Biomedical Health: better understanding of disease and health

Healthcare costs are rising. We can and will do something about it. In the context of the Biomedical Health roadmap, we are developing the tools and expertise needed to help companies, professionals and individuals generate and implement personalised health interventions. This will enable us to help prevent and cure diseases and to cut healthcare costs.

“Our ambition is to understand the causal mechanisms of diseases, and to use this knowledge in the development of well-founded tools and models. We are working with various companies to accelerate the process of developing medicines and functional foods, and to make it more efficient. The same goes for lifestyle interventions tailored to individual situations and needs. In this way, we will help to optimise the quality of care and to cut healthcare costs”, says Ivana Bobeldijk-Pastorova, the Biomedical Health programme manager.

Improving the medicine development process

It takes a lot of time and money to develop new medicines. This process could be improved by using better predictive tools and models in the preclinical process and by improving the design of clinical trials. Biomedical Health develops translational models, measurement tools, and modelling tools to help the developers of medicines and functional foods test the effectiveness and safety of their products more efficiently. This offers a range of benefits, such as reducing the failure rate of medicines in the later stages of their development, which also cuts costs.

Earlier detection and prediction

In an effort to predict someone’s risk of falling ill, we are trying to discover what triggers this disease and how it develops. Armed with a detailed knowledge of biomarkers (measurable indicators that can be detected in blood and other tissues) and with an understanding of disease mechanisms and human behaviour, we will be able to detect metabolic and immune diseases at an earlier stage and predict how they will develop in specific individuals.

Personalised interventions

Every individual is unique. An overweight individual’s risk of developing diabetes and other complications depends on factors such as lifestyle, environment, metabolism and genetics. It is not just a case of ‘one size fits all’. A specific intervention that works for one patient may not work in another. We use our extensive, in-depth biomedical expertise to help companies and healthcare professionals develop personalised interventions in the areas of metabolic and immune health. 

Research in human subjects and the power of predictive models

TNO is constantly seeking new insights and technologies to ensure that animal testing is used as effectively as possible, and to refine, reduce, and replace it wherever possible. The animal models we develop and use can be shown to accurately mimic human disease processes. We also use non-animal models, such as computer models  and organ-on-a-chip technology , which can improve and accelerate the development of new products, or we test these directly in human subjects . With all preclinical models, it is essential for us to know which elements of human physiology are accurately simulated and which are not.

Would you like to know more about our activities in the field of Biomedical Health or perhaps cooperate with us? Read the details below or get in touch with us.

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Contact

Dr. Ivana Bobeldijk PhD

  • biomedical research
  • health research
  • life sciences
  • metabolomics
  • analytical chemistry
Email

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